Changes in SpO2 on Room Air for 34 Severe COVID-19 Patients after Ivermectin-Based Combination Treatment: 62% Normalization within 24 Hours

The emergence of COVID-19 in March 2020 challenged Zimbabwe to respond with limited medical facilities and therapeutic options. Based on early clinical indications efficacy for the macrocyclic lactone, Ivermectin (IVM), against COVID-19, IVM-based combination treatments were deployed treat it. Oxygen saturation (SpO2) data retrospectively analyzed 34 severe, hypoxic patients all room air (without supplemental oxygen). patients, median age 56.5, treated at clinics or home between August May 2021. All but three these had significantly increased SpO2 values within 24 h after first IVM dose. mean increase as a percentage full normalization = 97 was 55.1% +12 62.3% +24 dose (paired t-test, p < 0.0000001). These results parallel similar sharp, rapid increases SpO2, air, mostly severe USA (California) who given an treatment. both critical series recovered. treatment stand sharp contrast declines associated pulmonary function through second week following onset moderate symptoms under standard care.